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Protective Effect of a Locked Retinal Chromophore Analog against Light-Induced Retinal Degeneration

Continuous regeneration of the 11-cis-retinal visual chromophore from all-trans-retinal is critical for vision. Insufficiency of 11-cis-retinal arising from the dysfunction of key proteins involved in its regeneration can impair retinal health, ultimately leading to loss of human sight. Delayed reco...

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Detalhes bibliográficos
Publicado no:Mol Pharmacol
Main Authors: Gao, Songqi, Parmar, Tanu, Palczewska, Grazyna, Dong, Zhiqian, Golczak, Marcin, Palczewski, Krzysztof, Jastrzebska, Beata
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6108575/
https://ncbi.nlm.nih.gov/pubmed/30018116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.112581
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