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Rational Tuning of Visual Cycle Modulator Pharmacodynamics
Modulators of the visual cycle have been developed for treatment of various retinal disorders. These agents were designed to inhibit retinoid isomerase [retinal pigment epithelium-specific 65 kDa protein (RPE65)], the rate-limiting enzyme of the visual cycle, based on the idea that attenuation of vi...
Guardat en:
| Publicat a: | J Pharmacol Exp Ther |
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| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The American Society for Pharmacology and Experimental Therapeutics
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5490204/ https://ncbi.nlm.nih.gov/pubmed/28476927 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.240721 |
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