Rational Tuning of Visual Cycle Modulator Pharmacodynamics

Modulators of the visual cycle have been developed for treatment of various retinal disorders. These agents were designed to inhibit retinoid isomerase [retinal pigment epithelium-specific 65 kDa protein (RPE65)], the rate-limiting enzyme of the visual cycle, based on the idea that attenuation of vi...

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Bibliografske podrobnosti
izdano v:J Pharmacol Exp Ther
Main Authors: Kiser, Philip D., Zhang, Jianye, Badiee, Mohsen, Kinoshita, Junzo, Peachey, Neal S., Tochtrop, Gregory P., Palczewski, Krzysztof
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2017
Teme:
Drug Discovery and Translational Medicine
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490204/
https://ncbi.nlm.nih.gov/pubmed/28476927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.240721
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