The novel PAR2 ligand C391 blocks multiple PAR2 signalling pathways in vitro and in vivo

BACKGROUND AND PURPOSE: Proteinase-activated receptor-2 (PAR2) is a GPCR linked to diverse pathologies, including acute and chronic pain. PAR2 is one of the four PARs that are activated by proteolytic cleavage of the extracellular amino terminus, resulting in an exposed, tethered peptide agonist. Se...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Boitano, Scott, Hoffman, Justin, Flynn, Andrea N, Asiedu, Marina N, Tillu, Dipti V, Zhang, Zhenyu, Sherwood, Cara L, Rivas, Candy M, DeFea, Kathryn A, Vagner, Josef, Price, Theodore J
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4562513/
https://ncbi.nlm.nih.gov/pubmed/26140338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13238
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