The novel PAR2 ligand C391 blocks multiple PAR2 signalling pathways in vitro and in vivo

BACKGROUND AND PURPOSE: Proteinase-activated receptor-2 (PAR2) is a GPCR linked to diverse pathologies, including acute and chronic pain. PAR2 is one of the four PARs that are activated by proteolytic cleavage of the extracellular amino terminus, resulting in an exposed, tethered peptide agonist. Se...

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Dettagli Bibliografici
Pubblicato in:Br J Pharmacol
Autori principali: Boitano, Scott, Hoffman, Justin, Flynn, Andrea N, Asiedu, Marina N, Tillu, Dipti V, Zhang, Zhenyu, Sherwood, Cara L, Rivas, Candy M, DeFea, Kathryn A, Vagner, Josef, Price, Theodore J
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley & Sons, Ltd 2015
Soggetti:
Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4562513/
https://ncbi.nlm.nih.gov/pubmed/26140338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13238
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