An Isoform specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes

cAMP-dependent protein kinase (PKA) is regulated in part by N-terminal myristylation of its catalytic (C) subunit. Structural information about the role of myristylation in membrane targeting of PKA has been limited. In mammalian cells there are four functionally non-redundant PKA Regulatory subunit...

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發表在:Structure
Main Authors: Zhang, Ping, Ye, Feng, Bastidas, Adam C., Kornev, Alexandr P., Wu, Jian, Ginsberg, Mark H., Taylor, Susan S.
格式: Artigo
語言:Inglês
出版: 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558360/
https://ncbi.nlm.nih.gov/pubmed/26278174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.07.007
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