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Assembly of allosteric macromolecular switches: lessons from PKA

Protein kinases are dynamic molecular switches that have evolved to be only transiently activated. Kinase activity is embedded within a conserved kinase core, which is typically regulated by associated domains, linkers and interacting proteins. Moreover, protein kinases are often tethered to large m...

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Detalles Bibliográficos
Autores principales: Taylor, Susan S., Ilouz, Ronit, Zhang, Ping, Kornev, Alexandr P.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985763/
https://ncbi.nlm.nih.gov/pubmed/22992589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrm3432
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