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Assembly of allosteric macromolecular switches: lessons from PKA
Protein kinases are dynamic molecular switches that have evolved to be only transiently activated. Kinase activity is embedded within a conserved kinase core, which is typically regulated by associated domains, linkers and interacting proteins. Moreover, protein kinases are often tethered to large m...
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| Glavni autori: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3985763/ https://ncbi.nlm.nih.gov/pubmed/22992589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrm3432 |
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