β(3)-Adrenoceptor activation relieves oxidative inhibition of the cardiac Na(+)-K(+) pump in hyperglycemia induced by insulin receptor blockade

Dysregulated nitric oxide (NO)- and superoxide (O(2)(·−))-dependent signaling contributes to the pathobiology of diabetes-induced cardiovascular complications. We examined if stimulation of β(3)-adrenergic receptors (β(3)-ARs), coupled to endothelial NO synthase (eNOS) activation, relieves oxidative...

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Publicado en:Am J Physiol Cell Physiol
Autores principales: Karimi Galougahi, Keyvan, Liu, Chia-Chi, Garcia, Alvaro, Fry, Natasha A., Hamilton, Elisha J., Figtree, Gemma A., Rasmussen, Helge H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556897/
https://ncbi.nlm.nih.gov/pubmed/26063704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00071.2015
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