Susceptibility of β1 Na(+)-K(+) Pump Subunit to Glutathionylation and Oxidative Inhibition Depends on Conformational State of Pump

Glutathionylation of cysteine 46 of the β1 subunit of the Na(+)-K(+) pump causes pump inhibition. However, the crystal structure, known in a state analogous to an E2·2K(+)·P(i) configuration, indicates that the side chain of cysteine 46 is exposed to the lipid bulk phase of the membrane and not expe...

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Hlavní autoři: Liu, Chia-Chi, Garcia, Alvaro, Mahmmoud, Yasser A., Hamilton, Elisha J., Galougahi, Keyvan Karimi, Fry, Natasha A. S., Figtree, Gemma A., Cornelius, Flemming, Clarke, Ronald J., Rasmussen, Helge H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320985/
https://ncbi.nlm.nih.gov/pubmed/22354969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.340893
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