Susceptibility of β1 Na(+)-K(+) Pump Subunit to Glutathionylation and Oxidative Inhibition Depends on Conformational State of Pump

Glutathionylation of cysteine 46 of the β1 subunit of the Na(+)-K(+) pump causes pump inhibition. However, the crystal structure, known in a state analogous to an E2·2K(+)·P(i) configuration, indicates that the side chain of cysteine 46 is exposed to the lipid bulk phase of the membrane and not expe...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Liu, Chia-Chi, Garcia, Alvaro, Mahmmoud, Yasser A., Hamilton, Elisha J., Galougahi, Keyvan Karimi, Fry, Natasha A. S., Figtree, Gemma A., Cornelius, Flemming, Clarke, Ronald J., Rasmussen, Helge H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Protein Structure and Folding
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320985/
https://ncbi.nlm.nih.gov/pubmed/22354969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.340893
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares