Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells

1. It has been suggested that acetaminophen (APAP)-protein adducts can be measured in circulation to diagnose APAP-induced liver injury. However, the full time course of plasma adducts has not been studied specifically in early-presenting overdose patients. In fact, surprisingly little work has been...

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Veröffentlicht in:Xenobiotica
Hauptverfasser: Xie, Yuchao, McGill, Mitchell R., Cook, Sarah F., Sharpe, Matthew R., Winefield, Robert D., Wilkins, Diana G., Rollins, Douglas E., Jaeschke, Hartmut
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4553102/
https://ncbi.nlm.nih.gov/pubmed/25869248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/00498254.2015.1026426
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