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Hearing, reactive metabolite formation, and oxidative stress in cochleae after a single acute overdose of acetaminophen: an in vivo study

CONTEXT: Although the liver is the primary target organ in acetaminophen (APAP) toxicity, other organs are affected. Previous data suggested chronic APAP abuse can be ototoxic and the mechanism involves APAP-induced oxidative stress and reactive metabolite (NAPQI)-induced endoplasmic reticulum stres...

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Detalhes bibliográficos
Publicado no:Toxicol Mech Methods
Main Authors: McGill, Mitchell R., Kennon-McGill, Stefanie, Durham, Dianne, Jaeschke, Hartmut
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940278/
https://ncbi.nlm.nih.gov/pubmed/26982240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/15376516.2015.1122136
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