Detection of Ultra-Rare Mitochondrial Mutations in Breast Stem Cells by Duplex Sequencing

Long-lived adult stem cells could accumulate non-repaired DNA damage or mutations that increase the risk of tumor formation. To date, studies on mutations in stem cells have concentrated on clonal (homoplasmic) mutations and have not focused on rarely occurring stochastic mutations that may accumula...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS One
Egile Nagusiak: Ahn, Eun Hyun, Hirohata, Kensen, Kohrn, Brendan F., Fox, Edward J., Chang, Chia-Cheng, Loeb, Lawrence A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2015
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4549069/
https://ncbi.nlm.nih.gov/pubmed/26305705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136216
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