Detection of Ultra-Rare Mitochondrial Mutations in Breast Stem Cells by Duplex Sequencing

Long-lived adult stem cells could accumulate non-repaired DNA damage or mutations that increase the risk of tumor formation. To date, studies on mutations in stem cells have concentrated on clonal (homoplasmic) mutations and have not focused on rarely occurring stochastic mutations that may accumula...

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Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Ahn, Eun Hyun, Hirohata, Kensen, Kohrn, Brendan F., Fox, Edward J., Chang, Chia-Cheng, Loeb, Lawrence A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2015
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4549069/
https://ncbi.nlm.nih.gov/pubmed/26305705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136216
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