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Decreased mitochondrial mutagenesis during transformation of breast stem cells into tumorigenic cells

Rare stochastic mutations may accumulate during dormancy of stem-like cells, but technical limitations in DNA sequencing have limited exploring this possibility. In this study, we employed a recently established deep sequencing method termed Duplex Sequencing to conduct a genome-wide analysis of mit...

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Bibliografiska uppgifter
I publikationen:Cancer Res
Huvudupphovsmän: Ahn, Eun Hyun, Lee, Seung Hyuk, Kim, Joon Yup, Chang, Chia-Cheng, Loeb, Lawrence A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004738/
https://ncbi.nlm.nih.gov/pubmed/27197159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-3462
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