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Detection of ultra-rare mutations by next-generation sequencing
Next-generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of ∼1% results in hundreds of millions of sequencing m...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3437896/ https://ncbi.nlm.nih.gov/pubmed/22853953 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1208715109 |
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