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Ultra-Sensitive Sequencing Reveals an Age-Related Increase in Somatic Mitochondrial Mutations That Are Inconsistent with Oxidative Damage

Mitochondrial DNA (mtDNA) is believed to be highly vulnerable to age-associated damage and mutagenesis by reactive oxygen species (ROS). However, somatic mtDNA mutations have historically been difficult to study because of technical limitations in accurately quantifying rare mtDNA mutations. We have...

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Detalles Bibliográficos
Main Authors: Kennedy, Scott R., Salk, Jesse J., Schmitt, Michael W., Loeb, Lawrence A.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784509/
https://ncbi.nlm.nih.gov/pubmed/24086148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003794
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