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Detection of ultra-rare mutations by next-generation sequencing

Next-generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of ∼1% results in hundreds of millions of sequencing m...

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Detalhes bibliográficos
Main Authors: Schmitt, Michael W., Kennedy, Scott R., Salk, Jesse J., Fox, Edward J., Hiatt, Joseph B., Loeb, Lawrence A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437896/
https://ncbi.nlm.nih.gov/pubmed/22853953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1208715109
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