Kindlin-3–mediated integrin adhesion is dispensable for quiescent but essential for activated hematopoietic stem cells

Hematopoietic stem cells (HSCs) generate highly dividing hematopoietic progenitor cells (HPCs), which produce all blood cell lineages. HSCs are usually quiescent, retained by integrins in specific niches, and become activated when the pools of HPCs decrease. We report that Kindlin-3–mediated integri...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Ruppert, Raphael, Moser, Markus, Sperandio, Markus, Rognoni, Emanuel, Orban, Martin, Liu, Wen-Hsin, Schulz, Ansgar S., Oostendorp, Robert A.J., Massberg, Steffen, Fässler, Reinhard
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4548061/
https://ncbi.nlm.nih.gov/pubmed/26282877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150269
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