Kindlin-3–mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption

The blood cell–specific kindlin-3 protein is required to activate leukocyte and platelet integrins. In line with this function, mutations in the KINDLIN-3 gene in man cause immunodeficiency and severe bleeding. Some patients also suffer from osteopetrosis, but the underlying mechanism leading to abn...

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Autori principali: Schmidt, Sarah, Nakchbandi, Inaam, Ruppert, Raphael, Kawelke, Nina, Hess, Michael W., Pfaller, Kristian, Jurdic, Pierre, Fässler, Reinhard, Moser, Markus
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2011
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3051823/
https://ncbi.nlm.nih.gov/pubmed/21357746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201007141
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