Kindlin-3–mediated integrin adhesion is dispensable for quiescent but essential for activated hematopoietic stem cells

Hematopoietic stem cells (HSCs) generate highly dividing hematopoietic progenitor cells (HPCs), which produce all blood cell lineages. HSCs are usually quiescent, retained by integrins in specific niches, and become activated when the pools of HPCs decrease. We report that Kindlin-3–mediated integri...

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Udgivet i:J Exp Med
Main Authors: Ruppert, Raphael, Moser, Markus, Sperandio, Markus, Rognoni, Emanuel, Orban, Martin, Liu, Wen-Hsin, Schulz, Ansgar S., Oostendorp, Robert A.J., Massberg, Steffen, Fässler, Reinhard
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4548061/
https://ncbi.nlm.nih.gov/pubmed/26282877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150269
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