Kindlin-3–mediated integrin adhesion is dispensable for quiescent but essential for activated hematopoietic stem cells

Hematopoietic stem cells (HSCs) generate highly dividing hematopoietic progenitor cells (HPCs), which produce all blood cell lineages. HSCs are usually quiescent, retained by integrins in specific niches, and become activated when the pools of HPCs decrease. We report that Kindlin-3–mediated integri...

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Bibliografiset tiedot
Julkaisussa:J Exp Med
Päätekijät: Ruppert, Raphael, Moser, Markus, Sperandio, Markus, Rognoni, Emanuel, Orban, Martin, Liu, Wen-Hsin, Schulz, Ansgar S., Oostendorp, Robert A.J., Massberg, Steffen, Fässler, Reinhard
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Rockefeller University Press 2015
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4548061/
https://ncbi.nlm.nih.gov/pubmed/26282877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150269
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