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Autophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of γ-secretase complex

Numerous studies have shown that autophagy failure plays a critical role in the pathogenesis of Alzheimer’s disease, including increased expression of beta-amyloid (Aβ) protein and the dysfunction of Aβ clearance. To further evaluate the role of autophagy in Alzheimer’s disease, the present study wa...

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Bibliographische Detailangaben
Veröffentlicht in:Neuropsychiatr Dis Treat
Hauptverfasser: Cai, Zhiyou, Zhou, Yingjun, Liu, Zhou, Ke, Zunyu, Zhao, Bin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove Medical Press 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547656/
https://ncbi.nlm.nih.gov/pubmed/26316755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/NDT.S84755
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