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CD147 is a regulatory subunit of the γ-secretase complex in Alzheimer's disease amyloid β-peptide production

γ-Secretase is a membrane protein complex that cleaves the β-amyloid precursor protein (APP) within the transmembrane region, after prior processing by β-secretase, producing amyloid β-peptides Aβ(40) and Aβ(42). Errant production of Aβ-peptides that substantially increases Aβ(42) production has bee...

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Detalhes bibliográficos
Main Authors: Zhou, Shuxia, Zhou, Hua, Walian, Peter J., Jap, Bing K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1103709/
https://ncbi.nlm.nih.gov/pubmed/15890777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0502768102
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