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CD147 is a regulatory subunit of the γ-secretase complex in Alzheimer's disease amyloid β-peptide production
γ-Secretase is a membrane protein complex that cleaves the β-amyloid precursor protein (APP) within the transmembrane region, after prior processing by β-secretase, producing amyloid β-peptides Aβ(40) and Aβ(42). Errant production of Aβ-peptides that substantially increases Aβ(42) production has bee...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2005
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1103709/ https://ncbi.nlm.nih.gov/pubmed/15890777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0502768102 |
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