Sorafenib Sensitizes Glioma Cells to the BH3 Mimetic ABT-737 by Targeting MCL1 in a STAT3-Dependent Manner()()

The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is overactivated in malignant glioma and plays a key role in promoting cell survival, thereby increasing the acquired apoptosis resistance of these tumors. Here we investigated the STAT3/myeloid cell leukem...

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Vydáno v:Neoplasia
Hlavní autoři: Kiprianova, Irina, Remy, Janina, Milosch, Nelli, Mohrenz, Isabelle V., Seifert, Volker, Aigner, Achim, Kögel, Donat
Médium: Artigo
Jazyk:Inglês
Vydáno: Neoplasia Press 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547411/
https://ncbi.nlm.nih.gov/pubmed/26297434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2015.07.003
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