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Actinomycin D synergistically enhances the efficacy of the BH3 mimetic ABT-737 by downregulating Mcl-1 expression

Many types of cancer cells possess the ability to evade apoptosis, leading to their rapid and uncontrolled proliferation. As major regulators of apoptosis, Bcl-2 proteins serve as emerging targets for novel chemotherapeutic strategies. In this study, we examined the involvement of Bcl-2 proteins in...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Olberding, Kristen E, Wang, Xiaoli, Zhu, Yanglong, Pan, Jianmin, Rai, Shesh N, Li, Chi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Landes Bioscience 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040859/
https://ncbi.nlm.nih.gov/pubmed/20818182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.10.9.13274
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