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BH3 mimetic ABT-737 sensitizes colorectal cancer cells to ixazomib through MCL-1 downregulation and autophagy inhibition

The proteasome inhibitor MLN9708 is an orally administered drug that is hydrolyzed into its active form, MLN2238 (ixazomib). Compared with Bortezomib, MLN2238 has a shorter proteasome dissociation half-life and a lower incidence and severity of peripheral neuropathy, which makes it an attractive can...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Am J Cancer Res
Päätekijät: Yang, Lifeng, Wan, Juefeng, Xiao, Sheng, Barkhouse, Darryll, Zhu, Ji, Li, Guichao, Lu, Bo, Zhang, Zhen
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: e-Century Publishing Corporation 2016
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937737/
https://ncbi.nlm.nih.gov/pubmed/27429848
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