Preclinical assessments of the MEK inhibitor PD-0325901 in a mouse model of neurofibromatosis type 1

BACKGROUND: Neurofibromatosis type 1 (NF1) is a genetic disorder that predisposes affected individuals to formation of benign neurofibromas, peripheral nerve tumors that can be associated with significant morbidity. Loss of the NF1 Ras-GAP protein causes increased Ras-GTP, and we previously found th...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Pediatr Blood Cancer
Autors principals: Jousma, Edwin, Rizvi, Tilat A., Wu, Jianqiang, Janhofer, David, Dombi, Eva, Dunn, Richard S., Kim, Mi-Ok, Masters, Andrea R., Jones, David R., Cripe, Timothy P., Ratner, Nancy
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546559/
https://ncbi.nlm.nih.gov/pubmed/25907661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.25546
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars