Preclinical assessments of the MEK inhibitor PD-0325901 in a mouse model of neurofibromatosis type 1

BACKGROUND: Neurofibromatosis type 1 (NF1) is a genetic disorder that predisposes affected individuals to formation of benign neurofibromas, peripheral nerve tumors that can be associated with significant morbidity. Loss of the NF1 Ras-GAP protein causes increased Ras-GTP, and we previously found th...

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Publicado no:Pediatr Blood Cancer
Main Authors: Jousma, Edwin, Rizvi, Tilat A., Wu, Jianqiang, Janhofer, David, Dombi, Eva, Dunn, Richard S., Kim, Mi-Ok, Masters, Andrea R., Jones, David R., Cripe, Timothy P., Ratner, Nancy
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546559/
https://ncbi.nlm.nih.gov/pubmed/25907661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.25546
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