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Preclinical assessments of the MEK inhibitor PD-0325901 in a mouse model of neurofibromatosis type 1
BACKGROUND: Neurofibromatosis type 1 (NF1) is a genetic disorder that predisposes affected individuals to formation of benign neurofibromas, peripheral nerve tumors that can be associated with significant morbidity. Loss of the NF1 Ras-GAP protein causes increased Ras-GTP, and we previously found th...
שמור ב:
| הוצא לאור ב: | Pediatr Blood Cancer |
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| Main Authors: | , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2015
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4546559/ https://ncbi.nlm.nih.gov/pubmed/25907661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.25546 |
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