TMOD-23. PRECLINICAL DRUG EVALUATION IN A GENETICALLY ENGINEERED MINIPIG MODEL OF NEUROFIBROMATOSIS TYPE 1

We have employed gene-editing technology to create a Neurofibromatosis Type 1 (NF1) minipig that replicates the broad spectrum of disease that develops in NF1 patients and meets the National Institute of Health’s diagnostic criteria for NF1. The NF1 boars are fertile and the NF1 mutant allele is tra...

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Xehetasun bibliografikoak
Argitaratua izan da:Neuro Oncol
Egile Nagusiak: Osum, Sara, Stemmer-Rachamimov, Anat, Widemann, Brigitte, Dombi, Eva, Vitte, Jeremie, Dahiya, Sonika, Rizvi, Tilat, Ratner, Nancy, Messiaen, Ludwine, Gutmann, David, Giovannini, Marco, Moertel, Christopher, Largaespada, David, Watson, Adrienne
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2019
Gaiak:
Tumor Models
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6845881/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.1122
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