MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors

Neurofibromatosis type 1 (NF1) patients develop benign neurofibromas and malignant peripheral nerve sheath tumors (MPNST). These incurable peripheral nerve tumors result from loss of NF1 tumor suppressor gene function, causing hyperactive Ras signaling. Activated Ras controls numerous downstream eff...

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Detalhes bibliográficos
Main Authors: Jessen, Walter J., Miller, Shyra J., Jousma, Edwin, Wu, Jianqiang, Rizvi, Tilat A., Brundage, Meghan E., Eaves, David, Widemann, Brigitte, Kim, Mi-Ok, Dombi, Eva, Sabo, Jessica, Hardiman Dudley, Atira, Niwa-Kawakita, Michiko, Page, Grier P., Giovannini, Marco, Aronow, Bruce J., Cripe, Timothy P., Ratner, Nancy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533264/
https://ncbi.nlm.nih.gov/pubmed/23221341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI60578
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