MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors

Neurofibromatosis type 1 (NF1) patients develop benign neurofibromas and malignant peripheral nerve sheath tumors (MPNST). These incurable peripheral nerve tumors result from loss of NF1 tumor suppressor gene function, causing hyperactive Ras signaling. Activated Ras controls numerous downstream eff...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Jessen, Walter J., Miller, Shyra J., Jousma, Edwin, Wu, Jianqiang, Rizvi, Tilat A., Brundage, Meghan E., Eaves, David, Widemann, Brigitte, Kim, Mi-Ok, Dombi, Eva, Sabo, Jessica, Hardiman Dudley, Atira, Niwa-Kawakita, Michiko, Page, Grier P., Giovannini, Marco, Aronow, Bruce J., Cripe, Timothy P., Ratner, Nancy
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2012
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533264/
https://ncbi.nlm.nih.gov/pubmed/23221341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI60578
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi