Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells

BACKGROUND: Many cancers show aberrant silencing of gene expression and overexpression of histone methyltransferases. The histone methyltransferases (HKMT) EZH2 and EHMT2 maintain the repressive chromatin histone methylation marks H3K27me and H3K9me, respectively, which are associated with transcrip...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Curry, Edward, Green, Ian, Chapman-Rothe, Nadine, Shamsaei, Elham, Kandil, Sarah, Cherblanc, Fanny L, Payne, Luke, Bell, Emma, Ganesh, Thota, Srimongkolpithak, Nitipol, Caron, Joachim, Li, Fengling, Uren, Anthony G., Snyder, James P., Vedadi, Masoud, Fuchter, Matthew J., Brown, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4545913/
https://ncbi.nlm.nih.gov/pubmed/26300989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-015-0118-9
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