PSF contacts exon 7 of SMN2 pre-mRNA to promote exon 7 inclusion

Spinal muscular atrophy (SMA) is an autosomal recessive genetic disease and a leading cause of infant mortality. Deletions or mutations in SMN1, a gene that encodes SMN protein, which regulates assembly/disassembly of U snRNP and are suggested to direct axonal transport of β-actin mRNA in neurons, a...

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Pubblicato in:Biochim Biophys Acta
Autori principali: Cho, Sunghee, Moon, Heegyum, Loh, Tiing Jen, Oh, Hyun Kyung, Williams, Darren Reese, Liao, D. Joshua, Zhou, Jianhua, Green, Michael R, Zheng, Xuexiu, Shen, Haihong
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4542050/
https://ncbi.nlm.nih.gov/pubmed/24632473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagrm.2014.03.003
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