3′ Splice Site Sequences of Spinal Muscular Atrophy Related SMN2 Pre-mRNA Include Enhancers for Nearby Exons

Spinal muscular atrophy (SMA) is a human genetic disease which occurs because of the deletion or mutation of SMN1 gene. SMN1 gene encodes the SMN protein which plays a key role in spliceosome assembly. Although human patients contain SMN2, a duplicate of SMN1, splicing of SMN2 produces predominantly...

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Autori principali: Cho, Sunghee, Moon, Heegyum, Loh, Tiing Jen, Oh, Hyun Kyung, Kim, Hey-Ran, Shin, Myung-Geun, Liao, D. Joshua, Zhou, Jianhua, Zheng, Xuexiu, Shen, Haihong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi Publishing Corporation 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3925570/
https://ncbi.nlm.nih.gov/pubmed/24616638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/617842
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