Assessment of Artificial MiRNA Architectures for Higher Knockdown Efficiencies without the Undesired Effects in Mice

RNAi-based strategies have been used for hypomorphic analyses. However, there are technical challenges to achieve robust, reproducible knockdown effect. Here we examined the artificial microRNA (amiRNA) architectures that could provide higher knockdown efficiencies. Using transient and stable transf...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Miura, Hiromi, Inoko, Hidetoshi, Tanaka, Masafumi, Nakaoka, Hirofumi, Kimura, Minoru, Gurumurthy, Channabasavaiah B., Sato, Masahiro, Ohtsuka, Masato
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4540464/
https://ncbi.nlm.nih.gov/pubmed/26285215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0135919
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