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Easi-CRISPR protocol for creating knock-in and conditional knockout mouse models using long ssDNA donors
CRISPR/Cas9-based genome editing can easily generate knockout mouse models by disrupting the gene sequence, but its efficiency for creating models that require either insertion of exogenous DNA (knock-in) or replacement of genomic segments is very poor. The majority of mouse models used in research...
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| Publicado no: | Nat Protoc |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6058056/ https://ncbi.nlm.nih.gov/pubmed/29266098 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nprot.2017.153 |
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