Binding of Complement Factor H (FH) Decreases Protective Anti-FH Binding Protein Antibody Responses of Infant Rhesus Macaques Immunized With a Meningococcal Serogroup B Vaccine

Background. The meningococcal vaccine antigen, factor H (FH)–binding protein (FHbp), binds human complement FH. In human FH transgenic mice, binding decreased protective antibody responses. Methods. To investigate the effect of primate FH binding, we immunized rhesus macaques with a 4-component sero...

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Podrobná bibliografie
Vydáno v:J Infect Dis
Hlavní autoři: Granoff, Dan M., Costa, Isabella, Konar, Monica, Giuntini, Serena, Van Rompay, Koen K. A., Beernink, Peter T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Major Articles and Brief Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4539902/
https://ncbi.nlm.nih.gov/pubmed/25676468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiv081
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