Binding of Complement Factor H (FH) Decreases Protective Anti-FH Binding Protein Antibody Responses of Infant Rhesus Macaques Immunized With a Meningococcal Serogroup B Vaccine

Background. The meningococcal vaccine antigen, factor H (FH)–binding protein (FHbp), binds human complement FH. In human FH transgenic mice, binding decreased protective antibody responses. Methods. To investigate the effect of primate FH binding, we immunized rhesus macaques with a 4-component sero...

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Publicado en:J Infect Dis
Autores principales: Granoff, Dan M., Costa, Isabella, Konar, Monica, Giuntini, Serena, Van Rompay, Koen K. A., Beernink, Peter T.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2015
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Major Articles and Brief Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4539902/
https://ncbi.nlm.nih.gov/pubmed/25676468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiv081
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