Heterogeneity in Rhesus Macaque Complement Factor H Binding to Meningococcal Factor H Binding Protein (FHbp) Informs Selection of Primates To Assess Immunogenicity of FHbp-Based Vaccines

Neisseria meningitidis causes disease only in humans. An important mechanism underlying this host specificity is the ability of the organism to resist complement by recruiting the complement downregulator factor H (FH) to the bacterial surface. In previous studies, binding of FH to one of the major...

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Detalhes bibliográficos
Publicado no:Clin Vaccine Immunol
Main Authors: Beernink, Peter T., Shaughnessy, Jutamas, Stefek, Heather, Ram, Sanjay, Granoff, Dan M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248754/
https://ncbi.nlm.nih.gov/pubmed/25185576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00517-14
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