Heterogeneity in Rhesus Macaque Complement Factor H Binding to Meningococcal Factor H Binding Protein (FHbp) Informs Selection of Primates To Assess Immunogenicity of FHbp-Based Vaccines

Neisseria meningitidis causes disease only in humans. An important mechanism underlying this host specificity is the ability of the organism to resist complement by recruiting the complement downregulator factor H (FH) to the bacterial surface. In previous studies, binding of FH to one of the major...

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Detalles Bibliográficos
Publicado en:Clin Vaccine Immunol
Main Authors: Beernink, Peter T., Shaughnessy, Jutamas, Stefek, Heather, Ram, Sanjay, Granoff, Dan M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2014
Assuntos:
Vaccines
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248754/
https://ncbi.nlm.nih.gov/pubmed/25185576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00517-14
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