Binding of Complement Factor H (FH) Decreases Protective Anti-FH Binding Protein Antibody Responses of Infant Rhesus Macaques Immunized With a Meningococcal Serogroup B Vaccine

Background. The meningococcal vaccine antigen, factor H (FH)–binding protein (FHbp), binds human complement FH. In human FH transgenic mice, binding decreased protective antibody responses. Methods. To investigate the effect of primate FH binding, we immunized rhesus macaques with a 4-component sero...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Infect Dis
Auteurs principaux: Granoff, Dan M., Costa, Isabella, Konar, Monica, Giuntini, Serena, Van Rompay, Koen K. A., Beernink, Peter T.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2015
Sujets:
Major Articles and Brief Reports
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4539902/
https://ncbi.nlm.nih.gov/pubmed/25676468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiv081
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