Binding of Complement Factor H (FH) Decreases Protective Anti-FH Binding Protein Antibody Responses of Infant Rhesus Macaques Immunized With a Meningococcal Serogroup B Vaccine

Background. The meningococcal vaccine antigen, factor H (FH)–binding protein (FHbp), binds human complement FH. In human FH transgenic mice, binding decreased protective antibody responses. Methods. To investigate the effect of primate FH binding, we immunized rhesus macaques with a 4-component sero...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Infect Dis
Päätekijät: Granoff, Dan M., Costa, Isabella, Konar, Monica, Giuntini, Serena, Van Rompay, Koen K. A., Beernink, Peter T.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2015
Aiheet:
Major Articles and Brief Reports
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4539902/
https://ncbi.nlm.nih.gov/pubmed/25676468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiv081
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