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fH-Dependent Complement Evasion by Disease-Causing Meningococcal Strains with Absent fHbp Genes or Frameshift Mutations()

Meningococci bind human fH to down-regulate complement, which enhances survival of the bacteria in serum. A major fH ligand is the vaccine candidate, factor H-binding protein (fHbp). Although fHbp has been considered an essential meningococcal virulence factor, rarely, invasive isolates with absent...

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Detalhes bibliográficos
Main Authors: Giuntini, Serena, Vu, David M., Granoff, Dan M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3756549/
https://ncbi.nlm.nih.gov/pubmed/23791680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2013.06.009
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