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Bactericidal Antibody Responses Elicited by A Meningococcal Outer Membrane Vesicle Vaccine with Over-Expressed fHbp and Genetically-Attenuated Endotoxin

BACKGROUND: Outer membrane vesicle (OMV) vaccines from mutant N. meningitidis strains engineered to over-express factor H-binding protein (fHbp) elicited broadly protective serum antibody responses in mice. The vaccines investigated were not treated with detergents to avoid extracting fHbp, which is...

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Detalhes bibliográficos
Main Authors: Koeberling, Oliver, Seubert, Anja Katharina, Granoff, Dan M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3755350/
https://ncbi.nlm.nih.gov/pubmed/18505380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/589308
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