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fH-Dependent Complement Evasion by Disease-Causing Meningococcal Strains with Absent fHbp Genes or Frameshift Mutations()
Meningococci bind human fH to down-regulate complement, which enhances survival of the bacteria in serum. A major fH ligand is the vaccine candidate, factor H-binding protein (fHbp). Although fHbp has been considered an essential meningococcal virulence factor, rarely, invasive isolates with absent...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3756549/ https://ncbi.nlm.nih.gov/pubmed/23791680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2013.06.009 |
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