Stimulation of Liver X Receptor Has Potent Anti-HIV Effects in a Humanized Mouse Model of HIV Infection

Previous studies demonstrated that liver X receptor (LXR) agonists inhibit human immunodeficiency virus (HIV) replication by upregulating cholesterol transporter ATP-binding cassette A1 (ABCA1), suppressing HIV production, and reducing infectivity of produced virions. In this study, we extended thes...

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Bibliografiske detaljer
Udgivet i:J Pharmacol Exp Ther
Main Authors: Ramezani, Ali, Dubrovsky, Larisa, Pushkarsky, Tatiana, Sviridov, Dmitri, Karandish, Sara, Raj, Dominic S., Fitzgerald, Michael L., Bukrinsky, Michael
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2015
Fag:
Chemotherapy, Antibiotics, and Gene Therapy
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538872/
https://ncbi.nlm.nih.gov/pubmed/26126533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.224485
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