HIV-1 Nef mobilizes lipid rafts in macrophages through a pathway that competes with ABCA1-dependent cholesterol efflux

HIV infection, through the actions of viral accessory protein Nef, impairs activity of cholesterol transporter ABCA1, inhibiting cholesterol efflux from macrophages and elevating the risk of atherosclerosis. Nef also induces lipid raft formation. In this study, we demonstrate that these activities a...

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Autors principals: Cui, Huanhuan L., Grant, Angela, Mukhamedova, Nigora, Pushkarsky, Tatiana, Jennelle, Lucas, Dubrovsky, Larisa, Gaus, Katharina, Fitzgerald, Michael L., Sviridov, Dmitri, Bukrinsky, Michael
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2012
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307646/
https://ncbi.nlm.nih.gov/pubmed/22262807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M023119
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