Liver X receptor agonist inhibits HIV-1 replication and prevents HIV-induced reduction of plasma HDL in humanized mouse model of HIV infection

HIV-infected subjects are at high risk of developing atherosclerosis, in part due to virus-induced impairment of HDL metabolism. Here, using as a model of HIV infection the NOD.Cg-Prkdc(scid)IL2rg(tm1Wjl)/SzJ (NSG) mice humanized by human stem cell transplantation, we demonstrate that LXR agonist TO...

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Autori principali: Dubrovsky, Larisa, Van Duyne, Rachel, Senina, Svetlana, Guendel, Irene, Pushkarsky, Tatiana, Sviridov, Dmitri, Kashanchi, Fatah, Bukrinsky, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294093/
https://ncbi.nlm.nih.gov/pubmed/22326260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2012.01.137
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