PML/RARα-regulated miR-181a/b-cluster targets the tumor suppressor RASSF1A in Acute Promyelocytic Leukemia

In acute promyelocytic leukemia (APL), all-trans-retinoic acid (ATRA) treatment induces granulocytic maturation and complete remission of leukemia. MicroRNAs are known to be critical players in the formation of the leukemic phenotype. In this study, we report downregulation of the miR-181a/b gene cl...

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Publicado en:Cancer Res
Autores principales: Bräuer-Hartmann, Daniela, Hartmann, Jens-Uwe, Wurm, Alexander A., Gerloff, Dennis, Katzerke, Christiane, Falzacappa, Maria Vittoria Verga, Pelicci, Pier Giuseppe, Müller-Tidow, Carsten, Tenen, Daniel G., Niederwieser, Dietger, Behre, Gerhard
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537849/
https://ncbi.nlm.nih.gov/pubmed/26041820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-3521
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